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Perspectives of drug-based neuroprotection targeting mitochondria

Archive ouverte | Procaccio, Vincent | CCSD

International audience. Mitochondrial dysfunction has been reported in most neurodegenerative diseases. These anomalies include bioenergetic defect, respiratory chain-induced oxidative stress, defects of mitochondri...

OPA1-related disorders: Diversity of clinical expression, modes of inheritance and pathophysiology

Archive ouverte | Chao de La Barca, Juan Manuel | CCSD

International audience. Mutations in the Optic Atrophy 1 gene (OPA1) were first identified in 2000 as the main cause of Dominant Optic Atrophy, a disease specifically affecting the retinal ganglion cells and the opt...

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Archive ouverte | Chao de la Barca, Juan Manuel | CCSD

International audience. Purpose : Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Altho...

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