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Differences in teratogenicity of some vitamin K antagonist substances used as human therapeutic or rodenticide are due to major differences in their fate after an oral administration

Archive ouverte | Chetot, Thomas | CCSD

International audience. All vitamin K antagonist active substances used as rodenticides were reclassified in 2016 by the European authorities as active substances "toxic for reproduction", using a "read-across" alte...

Vitamin K antagonist rodenticides display different teratogenic activity

Archive ouverte | Chetot, Thomas | CCSD

International audience. Vitamin K antagonists (VKA) are not recommended during pregnancy because warfarin (a first-generation VKA) is associated with a malformation syndrome "the fetal warfarin syndrome" (FWS). VKA ...

Overexpression of protein disulfide isomerase enhances vitamin K epoxide reductase activity

Archive ouverte | Chetot, Thomas | CCSD

International audience. Vitamin K epoxide reductase (VKOR) activity is catalyzed by the VKORC1 enzyme. It is a target of vitamin K antagonists (VKA). Numerous mutations of VKORC1 have been reported and are suspected...

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