Afficher la couverture 'The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming | Luque-Campos, Noymar' en grand format
/5

0 avis

The Macrophage Response Is Driven by Mesenchymal Stem Cell-Mediated Metabolic Reprogramming

Archive ouverte

Luque-Campos, Noymar | Bustamante-Barrientos, Felipe | Pradenas, Carolina | García, Cynthia | Araya, María Jesús | Bohaud, Candice | Contreras-López, Rafael | Elizondo-Vega, Roberto | Djouad, Farida | Luz-Crawford, Patricia | Vega-Letter, Ana María

Edité par CCSD ; Frontiers -

International audience. Mesenchymal stem cells (MSCs) are multipotent adult stromal cells widely studied for their regenerative and immunomodulatory properties. They are capable of modulating macrophage plasticity depending on various microenvironmental signals. Current studies have shown that metabolic changes can also affect macrophage fate and function. Indeed, changes in the environment prompt phenotype change. Therefore, in this review, we will discuss how MSCs orchestrate macrophage’s metabolic plasticity and the impact on their function. An improved understanding of the crosstalk between macrophages and MSCs will improve our knowledge of MSC’s therapeutic potential in the context of inflammatory diseases, cancer, and tissue repair processes in which macrophages are pivotal.

Suggestions

Du même auteur

Role of microRNA Shuttled in Small Extracellular Vesicles Derived From Mesenchymal Stem/Stromal Cells for Osteoarticular Disease Treatment

Archive ouverte | Lara-Barba, Eliana | CCSD

International audience. Osteoarticular diseases (OD), such as rheumatoid arthritis (RA) and osteoarthritis (OA) are chronic autoimmune/inflammatory and age-related diseases that affect the joints and other organs fo...

Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells

Archive ouverte | Pradenas, Carolina | CCSD

International audience. Background The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new approach to improve their immunotherapeutic abilities. This st...

Safety and efficacy of mesenchymal stromal cells mitochondria transplantation as a cell-free therapy for osteoarthritis

Archive ouverte | Vega-Letter, Ana Maria | CCSD

International audience. Objective: The inflammatory responses from synovial fibroblasts and macrophages and the mitochondrial dysfunction in chondrocytes lead to oxidative stress, disrupt extracellular matrix (ECM) ...

Chargement des enrichissements...