Syracuse

Non-Polio Enterovirus inhibitors : scaffolds, targets, and potency - what's new ?

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Roux, H.F.G. | Touret, Franck | Rathelot, P. | Sciò, P. | Coluccia, A. | Vanelle, P. | Roche, M.

Edité par CCSD -

Enterovirus (EV) is a genus that includes a large diversity of viruses spread around the world. They are the main cause of numerous diseases with seasonal clusters, like hand-foot-mouth disease (HFMD). A vaccine is marketed in China for the prevention of HFMD caused by EV-A71. Despite the need, no antiviral is marketed to date. Therefore, several compounds have been currently evaluated to inhibit non-polio Enterovirus (NPEV), namely direct antiviral agents and host target inhibitor. We propose to make a review of the latest molecules evaluated as NPEV inhibitors and to summarize structure-activity relationships between these inhibitors and their target. We provide access to all recent information on Enterovirus inhibitors, regardless of the species,to facilitate the design of future broad-spectrum drugs.

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