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Evolutionary and functional characterization of lagomorph guanylate-binding proteins: a story of gain and loss and shedding light on expression, localization and innate immunity-related functions

Archive ouverte | Schelle, Luca | CCSD

International audience. Guanylate binding proteins (GBPs) are an evolutionarily ancient family of proteins that are widely distributed among eukaryotes. They belong to the dynamin superfamily of GTPases, and their e...

Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes.

Archive ouverte | Korrodi-Gregório, Luís | CCSD

International audience. BACKGROUND: Pseudogenes are traditionally considered "dead" genes, therefore lacking biological functions. This view has however been challenged during the last decade. This is the case of th...

Maximum-likelihood approaches reveal signatures of positive selection in IL genes in mammals

Archive ouverte | Neves, Fabiana | CCSD

International audience. ILs are part of the immune system and are involved in multiple biological activities. ILs have been shown to evolve under positive selection; however, little information exists regarding whic...

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