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Structural Optimization of Azacryptands for Targeting Three‐Way DNA Junctions

Archive ouverte | Pipier, Angélique | CCSD

International audience. Transient melting of the duplex‐DNA (B‐DNA) during DNA transactions allows repeated sequences to fold into non‐B DNA structures, including DNA junctions and G‐quadruplexes. These noncanonical...

DNA junction ligands trigger DNA damage and are synthetic lethal with DNA repair inhibitors in cancer cells

Archive ouverte | Duskova, Katerina | CCSD

International audience. Translocation of DNA and RNA polymerases along their duplex substrates results in DNA supercoiling. This torsional stress promotes the formation of plectonemic structures, including three-way...

Dual targeting of higher-order DNA structures by azacryptands induces DNA junction-mediated DNA damage in cancer cells

Archive ouverte | Zell, Joanna | CCSD

International audience. DNA is intrinsically dynamic and folds transiently into alternative higher-order structures such as Gquadruplexes (G4s) and three-way DNA junctions (TWJs). G4s and TWJs can be stabilised by s...

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