Relationship between SARS-CoV-2 infection and ICU-acquired candidemia in critically ill medical patients: a multicenter prospective cohort study
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Reizine, Florian | Massart, Nicolas | Mansour, Alexandre | Fedun, Yannick | Machut, Anaïs | Vacheron, Charles-Hervé | Savey, Anne | Friggeri, Arnaud | Lepape, Alain | Alfandari, Serge | Allaire, Alexandra | Alvarez, Antonio | Nacim, Ammenouche | Argaus, Laurent | Audibert, Gérard | Aurel, Caroline | Bajolet, Odile | Barbut, Frédéric | Barjon, Genevieve | Baune, Patricia | Beague, Sébastien | Beilouny, Bassam | Bele, Nicolas | Belin, Nicolas | Bernerd, Cécile | Berrouane, Yasmina | Berrouba, Aziz | Bertrand, Julie | Bianchi, Claire | Biangoma, Sandrine | Birot Jaulin, Fabienne | Bonjean, Severine | Bordes-Couecou, Stéphanie | Bouhara, Abdenour | Bouillard, Philippe | Bourigault, Céline | Bourzeix, Sylvie | Boutreux, Sébastien | Bouzidi, Hanene | Brochart, Julie | Bulyez, Stéphanie | Callanquin, Marie | Canu, Nathalie | Capron, Matthieu | Carbognani, Daniel | Castelain, Vincent | Catanese, Vincent | Cattaneo, Isabelle | Chartier, Vanessa | Chassaing, Guillaume | Chausset, Robert | Chauvet, Mélanie | Chopin, Fabrice | Chubilleau, Catherine | Clayer, Céline | Cohen, Agnès | Comparot, Sylvie | Corne, Philippe | Cornesse, Marie-Elisabeth | Corno, Gaelle | Cortes, Esther | Courouble, Patricia | Crombe, Christian | Curnier, Véronique | Dabbachi, Monzer | Dananché, Cédric | Daroukh, Abla | Dassant, Damien | Daumas, Martine | Daurat, Aurélien | Deffarges, Dominique | Delanghe, Fanny | Delastre, Olivier | Delhomme, Joel | Délias, Jean Paul | Delorme, Martine | Derramond, Fabienne | Diaw, Frédérique | Dijols, Isabelle | Djedaini, Kamel | Dopeux, Loic | Duhoo, Sophie | Dulac, Thierry | Dupin, Clarisse | Dupont, Laurène | Durand, Michel | Durand Joly, Isabelle | Dusseau, Jean-Yves | Egreteau, Pierre Yves | Eldin, Carole | Espinasse, Florence | Farfour, Eric | Fatah, Abdelhamid | Ferreira, Luis | Fillatre, Pierre | Finge, Toufic | Fleurial, Véronique | Florentin, Arnaud | Fribourg, Agnès | Gallais-Hoff, Severine | Galland, Claude | Galliot, Richard | Garnier, Sylvain | Gasan, Gaelle | Gaubert-Duclos, Julien | Gauzere, Valérie | Geffriaud, Thomas | Geneau, Isabelle | Georges, Hughes | Gerbier Colomban, Solweig | Giacardi, Christophe | Gibot, Sebastien | Glanard, Audrey | Gleize, Marion | Goret, Marieline | Gourgues, Michele | Grau, Delphine | Grisi, Béatrice | Groleau, Clotilde | Grolier-Bois, Liliane | Guignabert, Catherine | Hadj-Slimane, Fethi | Hammad, Emmanuelle | Haond, Catherine | Hausermann, Marie Hélène | Hayo, Francoise | Henry, Christophe | Herbland, Alexandre | Huntzinger, Julien | Hyvernat, Hervé | Jean, Alexandre | Jolibois, Boris | Joron, Sylvie | Julien, Gauthier | Kempf, Jean | Knani, Lyes | La Combe, Béatrice | Labruyere, Marie | Lacroix, Sandrine | Lafon, Bruno | Lamant, Katia | Larroudé, Peggy | Launoy, Anne | Laurent, Bernadette | Lavigne, Thierry | Lawrence, Christine | Le, Quoc Vien | Le Coq, Muriel | Le Floch, Anne-Sophie | Le Fall, Fanny | Le Tallec, Brigitte | Lecoutre, Lucie | Ledochowski, Stanislas | Leon, Rusel | Lepouse, Claire | Lescot, Thomas | Levrard, Mélanie | Lier, Marie Laure | Lignereux, Anne | Louart, Benjamin | Maheu, Claire | Maindron, Aurélie | Mallard, Francois | Mallaret, Marie Reine | Mankikian, Bernard | Manzon, Christiane | Mardrus, Philippe | Mariot, Jacques | Martin, Audry | Martin, Emmanuelle | Martin, Maelle | Martres, Pascale | Maxime, Virginie | Meunier, Olivier | Meyer, Ella-Pauline | Meziani, Ferhat | Moschietto, Sébastien | Muller, Céline | Munier-Marion, Elodie | Neulier, Caroline | Nicolas, François | Nizou, Jacques-Yves | Palitta, Christine | Pascal, Michel | Passouant, Olivier | Patrigeon, René-Gilles | Pavillard, Frédérique | Peghaire, Sabine | Perdrix, Christophe | Petit, Jean-Sebastien | Pibre, Judith | Picard, Walter | Picault, Sylvie | Picos Gil, Santiago | Pillot, Jérôme | Pina, Patrick | Plattier, Rémi | Poiron, Laurent | Pommier, Christian | Pradel, Gaël | Prelipcean, Cristian | Pugliesi, Paul-Simon | Quenee, Vincent | Raposo, Olga | Remy, Eve | Reynaud Deforges, Sabine | Richard, Jean-Christophe | Ricome, Sylvie | Rimmele, Thomas | Robine, Adrien | Roche, Anne-Claude | Rohr, Laetitia | Rolland-Jacob, Gwenaël | Roques, Adrien | Rougier, Catherine | Roustan, Jérôme | Saint-Leger, Mélanie | Saliba, Faouzi | Sechaud, Dominique | Si-Ali, Amine | Simac, Catherine | Simon, Georges | Sirodot, Michel | Stoeckel, Vincent | Tagawa, Philippe | Tasle, Marine | Thiollière, Fabrice | Thiphagne, Benoit | Thomas-Hervieu, Aurélie | Tinturier, François | Tonnelier, Alexandre | Toro, Alexandre | Tranvan, David | Trivier, Dominique | Troché, Gilles | Trusson, Rémi | Ursulet, Lionel | Valdeyron, Marie Laure | Vallet, Catherine | van Rossem, Vanessa | Vasse, Laurence | Venelle, Myriam | Venot, Christine | Vieillard-Baron, Antoine | Vincent, Jean-François | Vitris, Michel | Yassine, Hussein | Zanre, Lassane | Zylberfajn, Cecile
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CCSD ; BioMed Central -
International audience.
BackgroundWhile SARS-CoV2 infection has been shown to be a significant risk-factor for several secondary bacterial, viral and Aspergillus infections, its impact on intensive care unit (ICU)-acquired candidemia (ICAC) remains poorly explored.MethodUsing the REA-REZO network (French surveillance network of ICU-acquired infections), we included all adult patients hospitalized for a medical reason of admission in participating ICUs for at least 48 h from January 2020 to January 2023. To account for confounders, a non-parsimonious propensity score matching was performed. Rates of ICAC according to SARS-CoV2 status were compared in matched patients. Factors associated with ICAC in COVID-19 patients were also assessed using a Fine-Gray model.ResultsA total of 55,268 patients hospitalized at least 48 h for a medical reason in 101 ICUs were included along the study period. Of those, 13,472 were tested positive for a SARS-CoV2 infection while 284 patients developed an ICAC. ICAC rate was higher in COVID-19 patients in both the overall population and the matched patients’ cohort (0.8% (107/13,472) versus 0.4% (173/41,796); p < 0.001 and 0.8% (93/12,241) versus 0.5% (57/12,241); p = 0.004, respectively). ICAC incidence rate was also higher in those patients (incidence rate 0.51 per 1000 patients-days in COVID-19 patients versus 0.32 per 1000 patients-days; incidence rate ratio: 1.58 [95% CI:1.08–2.35]; p = 0.018). Finally, patients with ICAC had a higher ICU mortality rate (49.6% versus 20.2%; p < 0.001).ConclusionIn this large multicenter cohort of ICU patients, although remaining low, the rate of ICAC was higher among COVID-19 patients.
