Dataset of zootechnical, biological, oocyte and embryo production indicators, from ewes with contrasted metabolic status and submitted to chronic bisphenol S exposure

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Desmarchais, A | Freret, Sandrine | Uzbekova, Svetlana | Maillard, Virginie | Elis, Sébastien

Edité par CCSD ; Elsevier -

International audience. This dataset consists of raw data from an experimental design in the ovine model: zootechnical traits, biological indicators, oocyte collection and embryo production from ewes with contrasted metabolic status and submitted to chronic Bisphenol S (BPS) exposure. For 2 consecutive years, 120 primiparous ewes (60 different ewes for each year) were managed in a loose sheepfold, assigned to two diet groups Restricted (R, n = 30) and Well-fed (WF, n = 30) and supplemented with or without BPS (0, 4 or 50 lg/kg/day), generating six experimental groups named R-0, R-4, R-50, WF-0, WF-4, and WF-50 (n = 10 ewes/group). Oocyte collection was carried out during the breeding season of sheep between September and December. Diet management started in May and BPS treatment started in June, that is to say at least 3 months before oocyte collection. The dataset presents zootechnical traits (age, live weight, body condition score), metabolic indicators and hormones concentrations measured in plasma (non-esterified fatty acids, glucose, thyroid hormones, Anti-Mullerian hormone, progesterone, oestradiol and other steroids) as well as in follicular fluid for some of them (progesterone, oestradiol and others steroids), BPS and BPS-glucuronide concentrations in plasma and urine, data from follicular puncture and oocyte collection by ovum pick-up followed by in vitro embryo production (during the 2nd year of experiment). This large dataset can be re-used on the one hand by researchers working on reproductive physiology in interaction with energy metabolism in ruminants, to further investigate the effects of a restricted diet; on the other hand, by toxicologists and endocrinologists to investigate the effects of BPS (potential endocrine disruptor) on several hormones (i.e. steroids) and metabolites.

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