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Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability

Archive ouverte | Berico, Pietro | CCSD

International audience. Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of key genes associated with cell function. The identification of cancer-specific SE-driven genes is a pow...

Super-enhancer-driven expression of BAHCC1 promotes melanoma cell proliferation and genome stability

Archive ouverte | Berico, Pietro | CCSD

Super-enhancers (SEs) are stretches of enhancers ensuring a high level of expression of key genes associated with cell function. The identification of cancer-specific SE-driven genes is a powerful means for the development of inno...

Active mRNA degradation by EXD2 nuclease elicits recovery of transcription after genotoxic stress

Archive ouverte | Sandoz, Jérémy | CCSD

International audience. Abstract The transcriptional response to genotoxic stress involves gene expression arrest, followed by recovery of mRNA synthesis (RRS) after DNA repair. We find that the lack of the EXD2 nuc...

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