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The biomechanical context influences the PI3K output signaling in breast and pancreatic cancer cells

Archive ouverte | Di-Luoffo, M. | CCSD

Abstract Mechanical stresses, including compressive stress, are well-recognized as being inherently triggered during cancer development. They are integrated by cells in biochemical signals through mechanotransduction. However, lit...

PI3K functions as a hub in mechanotransduction

Archive ouverte | Di-Luoffo, M. | CCSD

International audience. Mammalian cells integrate different types of stimuli that govern their fate. These stimuli encompass biochemical as well as biomechanical cues (shear, tensile, and compressive stresses) that ...

Potential Role of Sphingolipidoses-Associated Lysosphingolipids in Cancer

Archive ouverte | Dubot, P. | CCSD

International audience. Sphingolipids play a key structural role in cellular membranes and/or act as signaling molecules. Inherited defects of their catabolism lead to lysosomal storage diseases called sphingolipido...

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