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Angiogenesis inhibitor SR 25989 upregulates thrombospondin‐1 expression in human vascular endothelial cells and foreskin fibroblasts

Archive ouverte | Klein-Soyer, Claudine | CCSD

International audience. The aim of this work was to evaluate the effects of SR 25989, a member of the thienopyridine family devoid of antiplatelet activity but possessing anti‐angiogenic properties, on the regulatio...

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.. Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.: Role of myosin IIA in hemostasis and thrombosis

Archive ouverte | Léon, Catherine | CCSD

Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding disorders characterized by a macrothrombocytopenia. To understand the role of myosin in normal platelet functions and in pathology, we gen...

Synthesis of GPIbβ with novel transmembrane and cytoplasmic sequences in a Bernard–Soulier patient resulting in GPIb‐defective signaling in CHO cells

Archive ouverte | Strassel, Catherine | CCSD

International audience. The molecular defect of a new Bernard-Soulier patient, originating from Morocco and presenting thrombocytopenia with large platelets and an absence of ristocetin-induced platelet agglutinatio...

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