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Additive effects of TPMT and NUDT15 on thiopurine toxicity in children with acute lymphoblastic leukemia across multiethnic populations

Archive ouverte | Maillard, Maud | CCSD

International audience. Abstract Background Thiopurines such as mercaptopurine (MP) are widely used to treat acute lymphoblastic leukemia (ALL). Thiopurine-S-methyltransferase (TPMT) and Nudix hydrolase 15 (NUDT15) ...

Clinical Actionability of the NUDT15 * 4 (p. R139H ) Allele and Its Association With Hispanic Ethnicity

Archive ouverte | Maillard, Maud | CCSD

International audience. Nudix hydrolase 15 (NUDT15) deficiency is strongly associated with thiopurine‐induced myelosuppression. Currently, testing for NUDT15 deficiency is based on the genotyping of the most frequen...

An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling

Archive ouverte | Wijaya, Juwina | CCSD

International audience. Mutations in Sonic hedgehog (SHH) signaling promote aberrant proliferation and tumor growth. SHH-medulloblastoma (MB) is among the most frequent brain tumors in children less than 3 years of ...

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