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Enhanced cell viscosity: a new phenotype associated with lamin A/C alterations

Archive ouverte | Jebane, Cécile | CCSD

International audience. Lamin A/C is a well-established key contributor to nuclear stiffness and its role in nucleus mechanical properties has been extensively studied. However, its impact on whole cell mechanics ha...

Enhanced cell viscosity: a new phenotype associated with lamin A/C alterations

Archive ouverte | Jebane, Cécile | CCSD

Lamin A/C is a well-established key contributor to nuclear stiffness and its role in nucleus mechanical properties has been extensively studied. However, its impact on whole cell mechanics has been poorly addressed, even less so i...

A Rare Mutation in LMNB2 Associated with Lipodystrophy Drives Premature Cell Senescence

Archive ouverte | Varlet, Alice-Anaïs | CCSD

International audience. Many proteins are causative for inherited partial lipodystrophies, including lamins, the essential constituents of the nuclear envelope scaffold called the lamina. By performing high throughp...

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