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GPCR interaction as a possible way for allosteric control between receptors

Archive ouverte | Pin, Jean-Philippe | CCSD

International audience. For more than twenty years now, GPCR dimers and larger oligomers have been the subject of intense debate in the field. Evidence for a role of such complexes in receptor trafficking to and fro...

Chronic potentiation of metabotropic glutamate receptor 2 with a nanobody accelerates amyloidogenesis in Alzheimer’s disease.

Archive ouverte | Lafon, Pierre-André | CCSD

International audience. Immunotherapy of Alzheimer's disease (AD) is a promising approach to reduce the accumulation of amyloid-beta (Aβ), a critical event in the onset of the disease. Targeting the group II metabot...

Anti-mGluR2 biparatopic nanobodies and uses thereof

Archive ouverte | Pin, Jean-Philippe | CCSD

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