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The Polycomb landscape in mouse development

Archive ouverte | Richard Albert, Julien | CCSD

International audience. Polycomb-group proteins assemble into two primary complexes-Polycomb repressive complex (PRC) 1 and 2-that safeguard cell fate by repressing gene transcription. Two new studies explore the PR...

DNA methylation shapes the Polycomb landscape during the exit from naïve pluripotency

Archive ouverte | Albert, Julien Richard | CCSD

Abstract In mammals, 5 methyl-cytosine (5mC) and Polycomb Repressive Complex 2 (PRC2)-deposited histone 3 lysine 27 trimethylation (H3K27me3) are generally mutually exclusive at CpG-rich regions. As mouse embryonic stem cells exit...

Non-canonical imprinting in the spotlight

Archive ouverte | Albert, Julien Richard | CCSD

International audience. ABSTRACT Classical genomic imprints are regulated by parent-specific DNA methylation levels inherited from the gametes in mammals. Imprints control gene expression in a parent-of-origin manne...

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