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FKBP52 in Neuronal Signaling and Neurodegenerative Diseases: A Microtubule Story

Archive ouverte | Chambraud, Béatrice | CCSD

International audience. The FK506-binding protein 52 (FKBP52) belongs to a large family of ubiquitously expressed and highly conserved proteins (FKBPs) that share an FKBP domain and possess Peptidyl-Prolyl Isomerase...

Novel protective effect of mifepristone on detrimental GABA A receptor activity to immature Purkinje neurons

Archive ouverte | Rakotomamonjy, Jennifer | CCSD

International audience. Immature Purkinje neurons are particularly vulnerable cells. They survive in cerebellar slice cultures under treatment by the synthetic steroid mifepristone (RU486) that depolarizes them at t...

The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation.. The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation.: FKBP52 and Tubulin Functional interaction.

Archive ouverte | Chambraud, Béatrice | CCSD

The FK506 binding protein FKBP52 belongs to the large family of immunophilins and is known as a steroid receptor-associated protein. Previous data suggest that FKBP52 is associated with the motor protein dynein and with the cytosk...

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