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Archive ouverte | Bansard, Lucile | CCSD

ABSTRACT Tumor recurrence is often attributed to drug-tolerant cancer stem cells. We previously demonstrated that down regulation of the Pregnane X Receptor (PXR, NR1I2) decreases chemoresistance of cancer stem cells and prevents ...

Alternative therapeutic technologies to target undruggable proteins

Archive ouverte | Amblard, Muriel | CCSD

International audience. For decades, drug discovery mainly focused on the activation and inhibition of protein functions through the development of small molecules fitting into enzyme and receptor pockets. Although ...

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Archive ouverte | Kelly, Lois | CCSD

International audience. Dose-limiting toxicity poses a major limitation to the clinical utility of targeted cancer therapies, often arising from target engagement in nonmalignant tissues. This obstacle can be minimi...

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