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Do SMS/e-mail reminders increase influenza vaccination of rheumatoid arthritis patients under anti-TNF: a nested randomized controlled trial in the ART e-cohort
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Edité par CCSD ; Oxford University Press (OUP) -
International audience. Abstract Objectives The objectives of this study were to evaluate the effectiveness of short message service (SMS) and/or email reminders in improving influenza vaccination coverage rates among RA patients treated with anti-TNF therapies, and to identify factors associated with vaccination. Methods This study was a nested randomized controlled trial in the ART e-cohort, an ongoing French nationwide multicentre prospective cohort of RA patients treated with anti-TNF therapy. Patients were 1:1 randomized, with stratification on age. The intervention consisted of regular reminders via SMS and/or emails to get vaccinated against influenza during the vaccination campaign. At the end, all participants received a questionnaire. The primary outcome was influenza vaccination coverage. Secondary outcomes included the vaccination coverage before and after the COVID-19 pandemic, and factors associated with vaccination. Results Between October 2021 and April 2022, 446 participants were randomized (224 to the intervention group and 222 to the control group). Among them, 325 (73%) reported their vaccination status and 221 (68%) were vaccinated against influenza: 116/158 (73%) in the intervention group, vs 105/167 (63%) in the control group (relative risk 1.08; 95% CI 0.95–1.23). The vaccination coverage before and after the COVID-19 pandemic did not differ (72% vs 72%; 95% CI −8% to 8%). Age ≥65 years [odds ratio (OR) 6.25; 95% CI 2.88–13.60] and previous influenza vaccination in the years before inclusion (OR 7.81; 95% CI 4.36–14.02) were associated with higher rates of vaccination Conclusion SMS and/or e-mail reminders did not significantly improve influenza vaccination rates in our cohort. The COVID-19 pandemic did not substantially impact the influenza vaccination coverage. Our results might be counterbalanced by an already high vaccination coverage. Trial registration ClinicalTrials.gov, http://clinicaltrials.gov, NCT05220423, NCT03062865.
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