A computational model reveals an early transient decrease in fiber cross-linking that unlocks adult regeneration

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Pacary, Anastasia | Peurichard, Diane | Vaysse, Laurence | Monsarrat, Paul | Bolut, Clémence | Girel, Adeline | Guissard, Christophe | Lorsignol, Anne | Planat-Benard, Valérie | Paupert, Jenny | Ousset, Marielle | Casteilla, Louis

Edité par CCSD ; Springer Nature -

International audience. The decline in regeneration efficiency after birth in mammals is a significant roadblock for regenerative medicine in tissue repair. We previously developed a computational agent based-model (ABM) that recapitulates mechanical interactions between cells and the extracellular-matrix (ECM), to investigate key drivers of tissue repair in adults. Time calibration alongside a parameter sensitivity analysis of the model suggested that an early and transient decrease in ECM cross-linking guides tissue repair towards regeneration. Consistent with the computational model, transient inhibition or stimulation of fiber cross-linking for the first six days after subcutaneous adipose tissue (AT) resection in adult mice led to regenerative or scar healing, respectively. Therefore, this work positions the computational model as a predictive tool for tissue regeneration that with further development will behave as a digital twin of our in vivo model. In addition, it opens new therapeutic approaches targeting ECM cross-linking to induce tissue regeneration in adult mammals.

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