Syracuse

Genomics unveils country-to-country transmission between animal hospitals of a multidrug-resistant and sequence type 2 Acinetobacter baumannii clone. La génomique dévoile la transmission d'un pays à l'autre entre hôpitaux vétérinaires d'un clone d'Acinetobacter baumannii multirésistant et de séquence de type 2

Archive ouverte

André, Amédée | Plantade, Julie | Durieux, Isabelle | Durieu, Pauline | Godeux, Anne-Sophie | Decellieres, Maxence | Pouzot-Nevoret, Céline | Venner, Samuel | Charpentier, Xavier | Laaberki, Maria-Halima

Edité par CCSD ; Society for General Microbiology -

International audience. Acinetobacter baumannii is a globally distributed opportunistic pathogen in human health settings, including in intensive care units (ICUs). We investigated the contamination of a French small animal ICU with A. baumannii . We discovered repeated animal contamination by A. baumannii , and phylogenetic analysis traced contamination back to a potential foreign animal origin. Genomic analysis combined with antibiotic susceptibility testing revealed heteroresistance to penicillin and aminoglycoside mediated by insertion sequence dynamics and also suggest a potential cross-resistance to human-restricted piperacillin–tazobactam combination. The A. baumannii isolates of the animal ICU belong to the International Clone 2 commonly found in human health settings. Our results suggest a high adaptation of this lineage to healthcare settings and provide questions on the requirements for genetic determinants enabling adaptation to host and abiotic conditions.

• Description
• Sujet/Public
• Outil
• Outil d'anticipation
• Mémoire et thèse
• Gestion