Discovering novel microbially-conjugated bile acids with metabolomics

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Nothias, Louis-Félix

Edité par CCSD -

International audience. Recent advancements in mass spectrometry and computational metabolomics have opened new frontiers in understanding the complex interplay between the gut microbiome and host metabolism. In recent years, these techniques have been successfully employed by researchers to uncover the extent of novel bile acid conjugates produced by the human gut microbiome. In my presentation, I will not only describe these discoveries and their implications but also discuss the innovative experimental and computational methods that facilitated these findings. This includes our approach, which integrated combinatorial chemistry with artificial intelligence, and our preliminary translational analysis using public data repositories (Hoffmann, Nothias, Ludwig, et al. Nature. Biotechnology. 40, 411–421, 2022).

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