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Severe Malaria with Neurological Manifestations: What Contribution of Neurofilament Light Chain?

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Zayet, Souheil | Hagenkötter, Beate | Quadrio, Isabelle | Gendrin, Vincent | Klopfenstein, Timothée

Edité par CCSD ; Oxford University Press -

International audience. To the Editor—We have read with great interest the study conducted by Balanza et al, for the ROSI Study Group, entitled “Neurofilament light chain as a biomarker of neuronal damage in children with malaria” [1]. The authors have concluded that neurofilament light chain (NfL) levels increased over time in 167 children from Mozambique, aged 1–12 years, with uncomplicated (UM) and severe malaria (SM). They also elegantly demonstrated that the adjusted increase in NfL over 84 hours was higher in SM cases with neurological manifestations compared to SM without neurological manifestations and UM (P = .001 and P = .010, respectively). We would like to raise a few concerns for further discussion.

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