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Inferring Ligand-Receptor Interactions between GABAergic and Glutamatergic neurons during somatosensory cortex development

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Mathieu, Rémi | Corbières, Léa | Draia-Nicolau, Tangra | Govindan, Annousha | Bensa, Vianney | Pallesi-Pocachard, Emilie | Silvagnoli, Lucas | Represa, Alfonso | Cardoso, Carlos | Telley, Ludovic | de Chevigny, Antoine

Edité par CCSD -

The cerebral cortex contains a diversity of excitatory and inhibitory neuron types with specific positional and synaptic connectivity patterns, but the molecular mechanisms underlying this stereotypic organization are largely unknown. In search for LR pairs that regulate interactions and connectivity between cortical neurons during embryonic and postnatal development, we 5 tracked transcriptional dynamics of all genes for all cortical neuron types over 17 time points covering the entirety of cortical development. We then constructed a bioinformatic atlas to infer significant LR mediated interactions between all neuron types over cortex development. The atlas proved a strong observation validator and hypothesis generator by uncovering the essential role of two cadherin superfamily members in perisomatic inhibition of deep and superficial layer 10 excitatory neurons by neighboring parvalbumin-expressing basket cells.

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