Afficher la couverture 'Effects of Estrogens on Platelets and Megakaryocytes | Dupuis, Marion' en grand format
/5

0 avis

Effects of Estrogens on Platelets and Megakaryocytes

Archive ouverte

Dupuis, Marion | Severin, Sonia | Noirrit-Esclassan, Emmanuelle | Arnal, Jean-François | Payrastre, Bernard | Valéra, Marie-Cécile | Valera, Marie-Cecile

Edité par CCSD ; MDPI -

International audience. In women, oral menopausal hormonal therapy (MHT) is associated with adverse effects including an increased incidence of thromboembolic events, classically attributed to an increase in several liver-derived coagulation factors due to hepatic first pass. While platelets are central players in thrombus constitution, their implication in women treated with estrogens remains incompletely characterized. Platelets and their medullar progenitors, megakaryocytes, express estrogen receptors (ER) that may explain, at least in part, a sensitivity to hormonal changes. The purpose of this review is to summarize our current knowledge of estrogen actions on platelets and megakaryocytes in mice following in vivo administration and in women using MHT.

Suggestions

Du même auteur

Effect of chronic estradiol plus progesterone treatment on experimental arterial and venous thrombosis in mouse

Archive ouverte | Valéra, Marie-Cécile | CCSD

International audience. Postmenopausal hormone replacement therapy (HRT) with estrogen plus progestogens is the first line therapy to treat menopausal symptoms. The progestogen is added to estrogen to reduce or elim...

Effects of conjugated estrogen and bazedoxifene on hemostasis and thrombosis in mice

Archive ouverte | Noirrit-Esclassan, Emmanuelle | CCSD

International audience. Estrogen-progestin therapy was previously considered as the standard of care for managing bothersome symptoms associated with menopause, but it increases risks of breast cancer and of thrombo...

Vers une optimisation de la modulation du récepteur des œstrogènes dans le traitement hormonal de la ménopause

Archive ouverte | Valéra, Marie-Cécile | CCSD

International audience. Les femmes vivent désormais plus d’un tiers de leur vie après la survenue de la ménopause. Le déclin de la production d’œstrogènes endogènes au cours de cette période s’accompagne fréquemment...

Chargement des enrichissements...