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Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Archive ouverte | Le Voyer, Tom | CCSD

Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs)1,2, conferring a predisposition to life-threatening...

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Archive ouverte | Le Voyer, Tom | CCSD

International audience. Abstract Patients with autoimmune polyendocrinopathy syndrome type 1 (APS-1) caused by autosomal recessive AIRE deficiency produce autoantibodies that neutralize type I interferons (IFNs) 1,2...

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

Archive ouverte | Manry, Jérémy | CCSD

International audience. Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important t...

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