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In mice and humans, brain microvascular contractility matures postnatally

Archive ouverte | Slaoui, Leila | CCSD

International audience. Although great efforts to characterize the embryonic phase of brain microvascular system development have been made, its postnatal maturation has barely been described. Here, we compared the ...

In mice and humans, the brain’s blood vessels mature postnatally to acquire barrier and contractile properties

Archive ouverte | Slaoui, Leila | CCSD

Abstract The brain dense vascular network is essential for distributing oxygen and nutrients to neural cells. The network develops during embryogenesis and leads to the formation of the endothelial blood-brain barrier (BBB). This ...

Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit

Archive ouverte | Gilbert, Alice | CCSD

International audience. Absence of the astrocyte-specific membrane protein MLC1 is responsible for megalencephalic leukoencephalopathy with subcortical cysts (MLC), a rare type of leukodystrophy characterized by ear...

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