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Small RNA OxyS induces resistance to aminoglycosides during oxidative stress by controlling Fe-S cluster biogenesis in Escherichia coli

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Baussier, Corentin | Oriol, Charlotte | Durand, Sylvain | Py, Béatrice | Mandin, Pierre

Edité par CCSD ; National Academy of Sciences -

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This study sheds light on the regulatory mechanisms controlling the synthesis of essential Fe-S clusters in bacteria, revealing the roles for two small RNAs (FnrS and OxyS) in modulating the expression of the transcriptional regulator IscR. The findings suggest that this regulatory network could lead to bacterial resistance to aminoglycoside antibiotics during oxidative stress, a condition associated with chronic infections. Ultimately, this work highlights the importance of understanding the intricate regulatory networks controlling bacterial metabolism and adaptation to stress, which could have significant implications for public health.

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