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NK cell–derived GM-CSF potentiates inflammatory arthritis and is negatively regulated by CIS

Archive ouverte | Louis, Cynthia | CCSD

International audience. Despite increasing recognition of the importance of GM-CSF in autoimmune disease, it remains unclear how GM-CSF is regulated at sites of tissue inflammation. Using GM-CSF fate reporter mice, ...

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS

Archive ouverte | Delconte, Rebecca B. | CCSD

International audience. Natural killer (NK) cell activation is controlled by a balance of activating and inhibitory signals and cytokines such as IL-15. We previously identified cytokine-inducible SH2-containing pro...

Therapeutic blockade of activin-A improves NK cell function and antitumor immunity

Archive ouverte | Rautela, Jai | CCSD

International audience. Natural killer (NK) cells are innate lymphocytes that play a major role in immunosurveillance against tumor initiation and metastatic spread. The signals and checkpoints that regulate NK cell...

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