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Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1: involvement in controlling the YAP/Hippo signalling pathway and cell proliferation

Archive ouverte | Dupuy, Maryne | CCSD

International audience. BackgroundEwing sarcoma (ES), the second main pediatric bone sarcoma, is characterised by a chromosomal translocation leading to the formation of fusion proteins like EWS::FLI1. While several...

Ewing sarcoma from molecular biology to the clinic

Archive ouverte | Dupuy, Maryne | CCSD

International audience. In Europe, with an incidence of 7.5 cases per million, Ewing sarcoma (ES) is the second most common primary malignant bone tumor in children, adolescents and young adults, after osteosarcoma....

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Archive ouverte | Lavaud, Mélanie | CCSD

International audience. Osteosarcoma (OS) is the most common malignant bone tumor in children and teenagers. In many cases, such as poor response to treatment or the presence of metastases at diagnosis, the survival...

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