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Treatment by Posaconazole Tablets, Compared to Posaconazole Suspension, Does Not Reduce Variability of Posaconazole Trough Concentrations

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Gautier-Veyret, Elodie | Bolcato, Léa | Roustit, Matthieu | Weiss, Stéphanie | Tonini, Julia | Brenier-Pinchart, Marie-Pierre | Cornet, Muriel | Thiebaut-Bertrand, Anne | Stanke-Labesque, Françoise

Edité par CCSD ; American Society for Microbiology -

International audience. The delayed-release tablet formulation of posaconazole (POS-tab) results in higher plasma POS trough concentrations (C min ) than the oral suspension (POS-susp), which raises the question of the utility of therapeutic drug monitoring (TDM). We aimed to compare the variability of the POS C min for the two formulations and identify determinants of the POS-tab C min and its variability.

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