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Sialic acids cleavage induced by elastin-derived peptides impairs the interaction between insulin and its receptor in adipocytes 3T3-L1

Archive ouverte | Guillot, Alexandre | CCSD

International audience. The insulin receptor (IR) plays an important role in insulin signal transduction, the defect of which is believed to be the root cause of type 2 diabetes. In 3T3-L1 adipocytes as in other cel...

Production of Elastin-Derived Peptides Contribute to the Development of Nonalcoholic Steatohepatitis

Archive ouverte | Romier, Béatrice | CCSD

International audience. Affecting more than 30% of the western population, non-alcoholic fatty liver disease (NAFLD) is the most common liver disease and can lead to multiple complications including non-alcoholic st...

Impact of sialic acids on the molecular dynamic of bi-antennary and tri-antennary glycans

Archive ouverte | Guillot, Alexandre | CCSD

International audience. Sialic acids (SA) are monosaccharides that can be located at the terminal position of glycan chains on a wide range of proteins. The post-translational modifications, such as N-glycan chains,...

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