A comprehensive functional force velocity endurance (FoVE ) model reveals unsuspected muscle properties affected by the expression of DUX4

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Sohn, Solene | Bowen, Maximilien | Mariot, Virginie | Morel, Baptiste | Hourdé, Christophe | Dumonceaux, Julie

Edité par CCSD -

International audience. Measurements of muscle function is crucial to the assessment of potential treatments for muscular diseases To date, several force tests have been proposed in the literature such as the grip strength test and in situ measure of maximum muscle force producing capacity These experiments are realized under isometric conditions at null velocity, which does not reflect what happens in everyday life Here, we developed a Force Velocity Endurance FoVE model to i n situ compare the muscle functional capacities of the ACTA 1 MCM/+MCM/+( and ACTA 1 MCM/FLExDUX 4 (CD Cre+) transgenic mice The integrative FoVE model describes the evolution of the muscle force capacity simultaneously as a function of the contraction velocity and the time (i e fatigue) Experimentally, FoVE capacities were assessed during a fatiguing 180 s exercise by repeating maximal 100 Hz stimulation) shortening contractions performed at different velocities 2 to 15 mm s-1 This test provides a complete mapping of muscular function by describing the force production capacities at all velocity and fatigue levels This comprehensive functional force velocity endurance model reveals muscle properties affected by the expression of DUX 4 leading to a weaker, less powerful muscle but less quickly fatigable muscle

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