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Comorbid medical conditions are a key factor to understand the relationship between psychiatric disorders and COVID-19-related mortality: Results from 49,089 COVID-19 inpatients
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Edité par CCSD ; Nature Publishing Group -
International audience. Results from the recently published meta-analysis by Vai et al. [1]. indicate that psychiatric disorders may be associated with an increased risk of death after SARS-CoV-2 infection (pooled unadjusted OR = 2.00, 95%CI = 1.58–2.54; 23 studies including 43,938 participants with any psychiatric disorder and 1,425,793 control participants). These findings suggest that psychiatric disorders per se may be risk factors of death in COVID-19. However, a critical limitation for interpreting these findings is that only 9 of 23 studies included in that meta-analysis adjusted for a limited number of comorbid medical conditions. Because comorbid medical illnesses are more prevalent in people with psychiatric disorders than in the general population [2] and are associated with increased risk of COVID-19-related mortality [3, 4], this suggests that the association between psychiatric disorders and increased mortality in patients with COVID-19 may be confounded by medical comorbidities.
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