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FLT3 signaling inhibition abrogates opioid tolerance and hyperalgesia while preserving analgesia

Archive ouverte | Jouvenel, Antoine | CCSD

International audience. Navigating the duality of opioids' potent analgesia and side effects, including tolerance and hyperalgesia, is a significant challenge in chronic pain management, often prompting hazardous do...

FLT3 signaling inhibition preserves opioid analgesia while abrogating tolerance and hyperalgesia

Archive ouverte | Jouvenel, Antoine | CCSD

International audience. Opioid analgesia is counteracted on chronic use by tolerance and hyperalgesia inducing dose escalation and life-threatening overdoses. Mu opiate receptors (MOR) expressed in primary sensory n...

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

Archive ouverte | Rivat, Cyril | CCSD

International audience. Peripheral neuropathic pain (PNP) is a debilitating and intractable chronic disease, for which sensitization of somatosensory neurons present in dorsal root ganglia that project to the dorsal...

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