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Transcriptional regulation of congocidine (netropsin) biosynthesis and resistance

Archive ouverte | Vingadassalon, Audrey | CCSD

International audience. The production of specialized metabolites by Streptomyces bacteria is usually temporally regulated. This regulation is complex and frequently involves both global and pathway-specific mechani...

Transcriptional Regulation of Congocidine (Netropsin) Biosynthesis and Resistance

Archive ouverte | Vingadassalon, Audrey | CCSD

International audience. Understanding the mechanisms of regulation of specialized metabolite production can have important implications both at the level of specialized metabolism study (expression of silent gene cl...

An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens.

Archive ouverte | Juguet, Maud | CCSD

International audience. Congocidine (netropsin) is a pyrrole-amide (oligopyrrole, oligopeptide) antibiotic produced by Streptomyces ambofaciens. We have identified, in the right terminal region of the S. ambofaciens...

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