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Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis.. Platelet protease nexin-1, a serpin that strongly influences fibrinolysis and thrombolysis.: Platelet Protease Nexin-1 Is Antithrombolytic

Archive ouverte | Boulaftali, Yacine | CCSD

International audience. Background- Protease nexin-1 (PN-1) is a serpin that inhibits plasminogen activators, plasmin, and thrombin. PN-1 is barely detectable in plasma, but we have shown recently that PN-1 is prese...

Targeting protease nexin-1, a natural anticoagulant serpin, to control bleeding and improve hemostasis in hemophilia

Archive ouverte | Aymonnier, Karen | CCSD

International audience. Hemophilia A and B, diseases caused by the lack of factor VIII (FVIII) and factor IX (FIX) respectively, lead to insufficient thrombin production, and therefore to bleeding. New therapeutic s...

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Archive ouverte | François, Deborah | CCSD

International audience. Coagulation and fibrinolytic system deregulation has been implicated in the development of idiopathic pulmonary fibrosis, a devastating form of interstitial lung disease. We used intratrachea...

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