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Novel nanostructured lipid carriers dedicated to nucleic acid delivery for RNAi purposes

Archive ouverte | Bruniaux, Jonathan | CCSD

International audience. The specific down-regulation triggered through interference RNA (RNAi) provides a means to determine the gene functions and their contributions in an altered phenotype. In this way, high thro...

Novel nanostructured lipid carriers dedicated to nucleic acid delivery for RNAi purposes

Archive ouverte | Bruniaux, Jonathan | CCSD

International audience. RNA interference discovery has opened up new fields of study, including the understanding of dysregulation occurring in pathogenesis, especially in cancerogenesis. Through this mechanism, the...

Empirical model-based identification of critical quality attributes in the preclinical design of nanostructured lipid carriers

Archive ouverte | Bastogne, Thierry | CCSD

International audience. In this study, an empirical modelling-based method is proposed and implemented to identify the critical quality attributes and speed up the formulation optimization of a nanostructured lipid ...

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