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Biomimetic approach to decipher the mechanisms by which glycosaminoglycans regulate bone morphogenetic protein 2 (BMP2) signaling. Approche biomimétique pour déchiffrer les mécanismes de régulation de l'activité de la protéine-2 morphogénétique osseuse (BMP2) par les glycosaminoglycanes

Archive ouverte | Le Pennec, Jean | CCSD

Glycosaminoglycans (GAGs) are involved in various biological functions, regulating tissue homeostasis and cellular differentiation in the human body. These long polysaccharide chains interact with a wide range of proteins that mod...

BMP2 binds non-specifically to PEG-passivated biomaterials and induces substantial signaling

Archive ouverte | Le Pennec, Jean | CCSD

Biomaterials are widely employed across diverse biomedical applications and represent an attractive strategy to explore physiologically how extracellular matrix components influence the cellular response. In this study, we aimed t...

Sweet but Challenging: Tackling the Complexity of GAGs with Engineered Tailor‐Made Biomaterials

Archive ouverte | Pennec, Jean, Le | CCSD

International audience. Glycosaminoglycans (GAGs) play a crucial role in tissue homeostasis by regulating the activity and diffusion of bioactive molecules. Incorporating GAGs into biomaterials has emerged as a wide...

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