Long-term cellular immunity of vaccines for Zaire Ebola Virus Diseases
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Wiedemann, Aurélie | Lhomme, Edouard | Huchon, Mélanie | Foucat, Emile | Bérerd-Camara, Marion | Guillaumat, Lydia | Yaradouno, Marcel | Tambalou, Jacqueline | Rodrigues, Cécile | Ribeiro, Alexandre | Béavogui, Abdoul Habib | Lacabaratz, Christine | Thiébaut, Rodolphe | Richert, Laura | Lévy, Yves | Aboulhab, Jamila | Aguirre-Mackenzie, Michelle | Akoo, Pauline | Akpa, Esther | Akpata, Robert | Albert, Sara | Ale, Boni Maxime | Alimamy-Bangura, Serry | Andong, Pierre | Andrews, Benetta | Anoma, Stephane | Atri, Negin | Augier, Augustin | Awuondo, Ken | Ayouba, Ahidjo | Badio, Moses | Bagayoko, Aminata | Balde, Abby | Balssa, Joséphine | Bangura, Lamin Molecule | Barrington, Kesha | de Saint Fare, Eric Barte | Baseler, Beth | Bauder, Ali | Bauduin, Claire | Bawo, Luke | Beavogui, Abdoul Habib | Belson, Michael | Ben-Farhat, Safaa | Bererd, Marion | Bernaud, Nicolas | Beyslow, Teedoh | Biai, Neirade | Billioux, Jeanne | Billouin-Frazier, Shere | Binachon, Blandine | Blie, Julie | Bockstal, Viki | Boison, Patricia | Bolay, Fatorma | Boly, Aliou | Bonawitz, Rachael Elizabeth | Borg, Anne-Gaëlle | Bosompem, Samuel | Bozman, Courtney | Brady, Tyler | Browne, Sarah | Bullis, Ryan | Cagniard, Barbara | Cahill, Kelly | Cai, Yingyun | Camara, Aissata Abdoulaye | Camara, Aboubacar Keira | Camara, Alseny Modet | Campagne, Antoine | Campion, Cécilia | Cantan, Alexandre | Cash, Jennifer | Chai, Siew Pin | Chambelin, Francois | Chea, Michael | Chêne, Geneviève | Choi, Edouard | Chouinard, Michelle | Chung, Florence | Chung, Lucy | Ciancia, Séverine | Cisse, Papa Ndiaga | Cline-Cole, Elfrida | Colin, Céline | Coller, Beth-Ann | Conde, Djélikan Siaka | Cone, Katherine | Connor, Laurie | Connor, Nicholas | Cooper, Joseph Boye | Couffin-Cardiergues, Sandrine | Coulibaly, Fatoumata | Coulibaly, Mariam | Crew, Page | Dabakuyo-Yonli, Sandrine | Dabitao, Djeneba | Damerval, Thierry | Davis, Bionca | Deen, Gibrilla Fadlu | Dekeyster, Eline | Delfraissy, Jean-François | Delmas, Christelle | Diakite, Mahamadou | Diallo, Alpha | Diallo, Fatoumata Abdoulaye | Diallo, Mamadou Saliou | Diarra, Ayouba | Diarra, Samba | Diawara, Oualy | Dighero-Kemp, Bonnie | Diop, Samba | Diouf, Waly | Dixit, Saurabh | Djenabou, Barry | Doepel, Laurie | D’ortenzio, Eric | Doumbia, Seydou | Doumbia, Moussa Moise | Douoguih, Macaya | Dozier, Nelson | Cauwelaert, Natasha Dubois | Duchêne, Alain | Duvenhage, Michael | Eckes, Risa | Elliott, Elizabeth | Enria, Luisa | Espérou, Hélène | Etienne, Cécile | Eyler, Allison | Fakoli, Lawrence | Fallah, Mosoka | Fauvel, Marie-Alix | Faye, Sylvain | Fayiah, John | Fleck, Suzanne | Fofana, Vemy | Tchos, Karine Fouth | Franklin, Kokulo | Fusco, Daniela | Gaddah, Auguste | Gaignet, Marylène | Gallagher, Katherine | Gardner, Julie | Gichini, Harrison | Gozalbes, Julia Garcia | Grandits, Greg | Gray, Maima | Greenwood, Brian | Grobler, Nico | Gross, Robin | Grue, Louis | Grund, Birgit | Guindo, Oumar | Gupta, Swati | Haidara, Fadima | Hamzé, Benjamin | Hancox, Emma | Hébert, Jean-Christophe | Hendriks, Jenny | Hensley, Patricia | Hensley, Lisa | Herpin, Betsey | Higgs, Elisabeth | Hilton, Trudi | Hneino, Mickael | Höeltermannl, Tracey-Ann | Holley, Horace Preston | Hoover, Marie | Howard, Natasha | Hughes, Melissa | Ilo, Dicko | Irvine, Skip | Ishola, David | Jato, Yvonne | Joe, Madison | Johnson, Melvin | Kaba, Aboubacar Sidiki | Kagan, Jonathan | Kallon, Kade | Kamara, Michael | Kante, Myriam | Katoudi, Judith | Keita, Cheick Mohamed | Keita, Sakoba | Keita, Seykou | Kennedy, Stephen | Keshinro, Babajide | Kiawu, Hassan | Kieh, Mark | Killinger, Brent | Kinda, Moumouni | Kirchoff, Matthew | Kocher, Gregory | Kodio, Mamoudou | Kohn, Brian | Koivogui, Lamine | Kojan, Richard | Kolié, Cece Francis | Kolié, Jacques Seraphin | Kollie, David | Kopka, Stacy | Koroma, Bockarie | Kowuor, Dickens | Kpayieli-Freeman, Catherine | Kwast, Liane | Lacarra, Boris | Lambert, Laurie | Lambeth, Courtney | Lancrey-Javal, Solange | Lane, H. 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Recent Ebola outbreaks underscore the importance of continuous prevention and disease control efforts. Authorized vaccines include Merck’s Ervebo (rVSV-ZEBOV) and Johnson & Johnson’s two-dose combination (Ad26.ZEBOV/MVA-BN-Filo). Here, in a five-year follow-up of the PREVAC randomized trial (NCT02876328), we report the results of the immunology ancillary study of the trial. The primary endpoint is to evaluate long-term memory T-cell responses induced by three vaccine regimens: Ad26–MVA, rVSV, and rVSV–booster. Polyfunctional EBOV-specific CD4+ T-cell responses increase after Ad26 priming and are further boosted by MVA, whereas minimal responses are observed in the rVSV groups, declining after one year. In-vitro expansion for eight days show sustained EBOV-specific T-cell responses for up to 60 months post-prime vaccination with both Ad26-MVA and rVSV, with no decline. Cytokine production analysis identify shared biomarkers between the Ad26-MVA and rVSV groups. In secondary endpoint, we observed an elevation of pro-inflammatory cytokines at Day 7 in the rVSV group. Finally, we establish a correlation between EBOV-specific T-cell responses and anti-EBOV IgG responses. Our findings can guide booster vaccination recommendations and help identify populations likely to benefit from revaccination.
