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Prenatal exposure to persistent organic pollutants and body mass index trajectories from birth to age 12
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International audience. BACKGROUND AND AIM[|]Several studies have explored the association between prenatal exposure to persistent organic pollutants (POPs) and body mass index (BMI) at a given age but very few have evaluated the dynamic of growth across ages. Our objective was to study the associations between prenatal exposure to multiple POPs and growth BMI trajectories from birth to adolescence.[¤]METHOD[|]This study included 430 mother-child pairs enrolled in the PELAGIE cohort (France). Polychlorinated biphenyls (PCBs), organochlorine pesticides (OCs), and per- and polyfluorinated substances (PFASs) were measured in cord blood. Latent class growth model was used to identify BMI z-score (zBMI) trajectories. Multinomial regressions evaluated the associations between each POP and the resulting zBMI trajectories, as well as Quantile G-computation to evaluate POP mixture effects. All analyses were stratified by sex and adjusted for confounders.[¤]RESULTS[|]Four classes of zBMI trajectories were identified and the “average zBMI at birth and lower zBMI up to age 12” trajectory was considered as the reference. In single-exposure models, higher exposure to beta-hexachlorocyclohexane (b-HCH) was associated with a higher odds of following the “higher zBMI from birth to age 12” trajectory (OR=1.5 [1.1;2.1]). In girls, higher exposure to all PCBs was associated with higher odds of following the trajectory “lower zBMI at birth with accelerated zBMI gain in early childhood before stabilization up to age 12”; this association was also observed in the mixture analysis (OR=1.2 [1.0;1.5]). In boys, higher exposure to some PFASs was associated with higher odds of following the “higher zBMI from birth to adolescence” trajectory and lower odds of following the “lower zBMI from birth to adolescence” trajectory.[¤]CONCLUSIONS[|]Prenatal exposure to POPs may be associated with some specific growth dynamics, known as risk factors for adult cardiovascular health.
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