A population of Insula neurons encodes for social preference only after acute social isolation in mice

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Glangetas, Christelle | Guillaumin, Adriane | Ladevèze, Elodie | Braine, Anaelle | Gauthier, Manon | Bonamy, Léa | Doudnikoff, Evelyne | Dhellemmes, Thibault | Landry, Marc | Bézard, Erwan | Caille, Stephanie | Taupignon, Anne | Baufreton, Jérôme | Georges, François

Edité par CCSD ; Nature Publishing Group -

International audience. The Insula functions as a multisensory relay involved in socio-emotional processing with projections to sensory, cognitive, emotional, and motivational regions. Notably, the interhemispheric projection from the Insula to the contralateral Insula is a robust yet underexplored connection. Using viral-based tracing neuroanatomy, ex vivo and in vivo electrophysiology, in vivo fiber photometry along with targeted circuit manipulation, we elucidated the nature and role of Insula^Ins communication in social and anxiety processing in mice. In this study, we 1) characterized the anatomical and molecular profile of the Insula^Ins neurons, 2) demonstrated that stimulation of this neuronal subpopulation induces excitation in the Insula interhemispheric circuit, 3) revealed that InsulaIns neurons are essential for social discrimination after 24 h of isolation in male mice. In conclusion, our findings highlight InsulaIns neurons as a distinct class of neurons within the insula and offer new insights into the neuronal mechanisms underlying social behavior.

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