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Biosynthesis of natural and halogenated plant monoterpene indole alkaloids in yeast

Archive ouverte | Bradley, Samuel | CCSD

International audience. Abstract Monoterpenoid indole alkaloids (MIAs) represent a large class of plant natural products with marketed pharmaceutical activities against a wide range of indications, including cancer,...

A microbial supply chain for production of the anti-cancer drug vinblastine

Archive ouverte | Zhang, Jie | CCSD

International audience. Abstract Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinbl...

The Rauvolfia tetraphylla genome suggests multiple distinct biosynthetic routes for yohimbane monoterpene indole alkaloids

Archive ouverte | Stander, Emily Amor | CCSD

International audience. Monoterpene indole alkaloids (MIAs) are a structurally diverse family of specialized metabolites mainly produced in Gentianales to cope with environmental challenges. Due to their pharmacolog...

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