D-chiro-inositol in clinical practice: A perspective from The Experts Group on Inositol in Basic and Clinical Research (EGOI)

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Dinicola, S. | Unfer, V. | Soulage, C. O. | Yap-Garcia, M. I. M. | Bevilacqua, A. | Benvenga, S. | Barbaro, D. | Wdowiak, A. | Nordio, M. | Dewailly, D. | Appetecchia, M. | Aragona, C. | Espinola, M. S. B. | Bizzarri, M. | Cavalli, P. | Colao, A. | d'Anna, R. | Vazquez-Levin, M. H. | Hernández Marín, I. | Kamenov, Z. | Laganà, A. S. | Monastra, G. | Montanino Oliva, M. | Cenk Özay, A. | Pintaudi, B. | Porcaro, G. | Pustotina, O. | Pkhaladze, L. | Prapas, N. | Roseff, S. | Salehpour, S. | Stringaro, A. | Tugushev, M. | Vucenik, I. | Facchinetti, F.

Edité par CCSD ; Karger -

BACKGROUND: D-chiro-inositol is a natural molecule that, in association with its well-studied isomer myo-inositol, may play a role in treating various metabolic and gynecological disorders. OBJECTIVES: This perspective seeks to explore the mechanisms and functions of D-chiro-inositol, laying the foundations to discuss its use in clinical practice, across dysmetabolism, obesity, and hormonal dysregulation. METHODS: A narrative review of all the relevant papers known to the authors was conducted. OUTCOME: D-chiro-inositol acts through a variety of mechanisms, acting as an insulin sensitizer, inhibiting the transcription of aromatase, in addition to modulating white adipose tissue/brown adipose tissue trans differentiation. These different modes of action have potential applications in a variety of therapeutic fields including: PCOS, dysmetabolism, obesity, hypoestrogenic/hyperandrogenic disorders, and bone health. CONCLUSIONS: D-chiro-inositol mode of action has been studied in detail in recent years, resulting in a clear differentiation between D-chiro-inositol and its isomer myo-inositol. The insulin sensitizing activities of D-chiro-inositol are well understood; however, its potential applications in other fields, in particular obesity and hyperestrogenic/hypoandrogenic disorders in men and women, represent promising avenues of research that require further clinical study.

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