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Recent updates for VIGIMYC, a settled 20-year old surveillance network dedicated to ruminant mycoplasmas
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International audience. For over 20 years, the so-called VIGIMYC network has enabled the passive surveillance of ruminant mycoplasmas over the French territory, including WOAH regulated diseases.VIGIMYC has grown overtime and, since 2013, around 500 documented clinical isolates have been collected each year from veterinary diagnostic laboratories (VDLs) and identified at the (sub)species level. New initiatives have recently been launched to improve the service provided by VIGIMYC and further extend its impact within and across borders. First, since 2018, we have investigated the antimicrobial resistance (AMR) trends of major pathogenic mycoplasma species on collected isolates. While the Minimum Inhibitory Concentrations (MICs) of small ruminant mycoplasmas remain predominantly low, Mycoplasmopsis (M.) bovis (formerly Mycoplasma bovis) shows moderate or high MICs for all the tested antimicrobials except fluoroquinolones. Surprisingly, we observed a decrease of spectinomycin MICs in M. bovis lately, which could be associated to the subtypes currently circulating in France.Consolidated MIC data from VIGIMYC will contribute to establishing future tECOFF within the MyMIC network (https://www.jpiamr.eu/projects/mymic/). Since 2020, annual surveys were performed to get insight on positivity testing rates of major pathogenic mycoplasma, reaching a proxy of their prevalence. Collected data complemented relative proportions of identified mycoplasmas and allowed monitoring diagnostic volume. Important differences were observed, cattle being the most monitored species by far and M. bovis detection rate in respiratory samples has increased from 14 to 19% between 2020 and 2022. VIGIMYC also provides a solid technical and scientific support to VDLs. In 2023-2024, proficiency tests and trainings were organized to help partner VDLs in learning and maintaining adequate diagnostic practices. Lastly, a selection of clinical isolates are stored yearly enabling the set-up of a collection of more than 2600 isolates to date, which are increasingly being used for whole genome sequence comparison studies that provide a better understanding of the diversity and evolution of mycoplasmas. VIGIMYC is a dynamic network aiming to improve diagnosticand AMR surveillance for several mycoplasmoses in France. Its output reaches far beyond the French borders and the issue of diagnostic, with an increasing contribution to AMR surveillance and follow up of mycoplasma genomic evolution within Europe.
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