Prediction of Acute Pulmonary Toxicity Events with 3D Convolutional Neural Networks from Radiotherapy Dose Maps

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Soto Vega, Pedro Juan | Bourbonne, Vincent | Marchadour, Wistan | Andrade-Miranda, Gustavo | Lucia, Francois | Rehn, Martin | Schick, Ulrike | Visvikis, Dimitris | Vermet, Franck | Hatt, Mathieu

Edité par CCSD -

International audience. Predicting toxicity events in radiation therapy (RT) is highly beneficial for managing patients effectively. Identifying patients who are at a high risk of experiencing toxicity early on during their treat- ments can help in taking measures to reduce the risk of adverse events produced by this undesirable effect. Recent works in a related application, namely, acute pulmonary toxicity (APT) in lung cancer patients treated by RT, have demonstrated high accuracy in predicting such an event using dose maps features processed by a multilayer perception network. Thus, motivated by the success of convolutional neural networks (CNN) in learning semantically rich representation directly from images, this work investigates the suitability of CNN architectures in predicting APT directly from dose maps. Our results demonstrate the ability of some CNN models to predict APT from planning dose maps with an accuracy of up to 81% in terms of receiver operative characteristic’s area under the curve. However, most of the architectures and configurations under evaluation led to non-satisfactory accuracy, as only shallower architectures using resized dose maps as inputs were able to train models with good accuracy in the testing set.

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