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Cell cycle-coordinated maintenance of the Vibrio bipartite genome

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Niault, Théophile | Czarnecki, Jakub | Lambérioux, Morgan | Mazel, Didier | Val, Marie-Eve

Edité par CCSD ; American Society for Microbiology -

International audience. ABSTRACT To preserve the integrity of their genome, bacteria rely on several genome maintenance mechanisms that are co-ordinated with the cell cycle. All members of the Vibrio family have a bipartite genome consisting of a primary chromosome (Chr1) homologous to the single chromosome of other bacteria such as Escherichia coli and a secondary chromosome (Chr2) acquired by a common ancestor as a plasmid. In this review, we present our current understanding of genome maintenance in Vibrio cholerae , which is the best-studied model for bacteria with multi-partite genomes. After a brief overview on the diversity of Vibrio genomic architecture, we describe the specific, common, and co-ordinated mechanisms that control the replication and segregation of the two chromosomes of V. cholerae . Particular attention is given to the unique checkpoint mechanism that synchronizes Chr1 and Chr2 replication.

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Peer review informationNature Microbiology thanks Sandra Da Re, Louis-Marie Bobay and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available.. International au...

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