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Biology and physiology of tendon healing

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Darrieutort-Laffite, Christelle | Blanchard, Frédéric | Soslowsky, Louis, J | Le Goff, Benoit

Edité par CCSD ; Elsevier Masson -

International audience. Tendon disorders affect people of all ages, from elite and recreational athletes and workers to elderlypatients. After an acute injury, 3 successive phases are described to achieve healing: an inflammatoryphase followed by a proliferative phase, and finally by a remodeling phase. Despite this process, healedtendon fails to recover its original mechanical properties. In this review, we proposed to describe thekey factors involved in the process such as cells, transcription factors, extracellular matrix components,cytokines and growth factors and vascularization among others. A better understanding of this healingprocess could help provide new therapeutic approaches to improve patients’ recovery while tendondisorders management remains a medical challenge.

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