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Detection of the human GPR50 orphan seven transmembrane protein by polyclonal antibodies mapping different epitopes

Archive ouverte | Hamouda, Hassina Ould | CCSD

International audience. GPR50 is an orphan seven transmembrane protein related to the melatonin receptor subfamily comprising MT(1) and MT(2) receptors. In the absence of any known ligand for GPR50, other tools are ...

The orphan GPR50 receptor promotes constitutive TGFβ receptor signaling and protects against cancer development

Archive ouverte | Wojciech, Stefanie | CCSD

International audience. Abstract Transforming growth factor-β (TGFβ) signaling is initiated by the type I, II TGFβ receptor (TβRI/TβRII) complex. Here we report the formation of an alternative complex between TβRI a...

The PDZ Protein Mupp1 Promotes G i Coupling and Signaling of the Mt 1 Melatonin Receptor

Archive ouverte | Guillaume, Jean-Luc | CCSD

International audience. Intracellular signaling events are often organized around PDZ (PSD-95/Drosophila Disc large/ZO-1 homology) domain-containing scaffolding proteins. The ubiquitously expressed multi-PDZ protein...

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