Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort
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Casco, Nicolas | Jorge, Alberto Levi | Palmero, Domingo Juan | Alffenaar, Jan-Willem | Fox, Greg | Ezz, Wafaa | Cho, Jin-Gun | Denholm, Justin | Skrahina, Alena | Solodovnikova, Varvara | Arbex, Marcos Abdo | Alves, Tatiana | Rabahi, Marcelo Fouad | Pereira, Giovana Rodrigues | Sales, Roberta | Silva, Denise Rossato | Saffie, Muntasir | Salinas, Nadia Escobar | Miranda, Ruth Caamaño | Cisterna, Catalina | Concha, Clorinda | Fernandez, Israel | Villalón, Claudia | Vera, Carolina Guajardo | Tapia, Patricia Gallegos | Cancino, Viviana | Carbonell, Monica | Cruz, Arturo | Muñoz, Eduardo | Muñoz, Camila | Navarro, Indira | Pizarro, Rolando | Cristina Sánchez, Gloria Pereira | Vergara Riquelme, Maria Soledad | Vilca, Evelyn | Soto, Aline | Flores, Ximena | Garavagno, Ana | Bahamondes, Martina Hartwig | Merino, Luis Moyano | Pradenas, Ana María | Revillot, Macarena Espinoza | Rodriguez, Patricia | Salinas, Angeles Serrano | Taiba, Carolina | Valdés, Joaquín Farías | Subiabre, Jorge Navarro | Ortega, Carlos | Palma, Sofia | Castillo, Patricia Perez | Pinto, Mónica | Bidegain, Francisco Rivas | Venegas, Margarita | Yucra, Edith | Li, Yang | Cruz, Andres | Guelvez, Beatriz | Victoria Plaza, Regina | Tello Hoyos, Kelly Yoana | Cardoso-Landivar, José | van den Boom, Martin | Andréjak, Claire | Blanc, François-Xavier | Dourmane, Samir | Froissart, Antoine | Izadifar, Armine | Rivière, Frédéric | Schlemmer, Frédéric | Manika, Katerina | Diallo, Boubacar Djelo | Hassane-Harouna, Souleymane | Artiles, Norma | Mejia, Licenciada Andrea | Gupta, Nitesh | Ish, Pranav | Mishra, Gyanshankar | Patel, Jigneshkumar | Singla, Rupak | Udwadia, Zarir | Alladio, Francesca | Angeli, Fabio | Calcagno, Andrea | Centis, Rosella | Codecasa, Luigi Ruffo | de Lauretis, Angelo | Esposito, Susanna M.R. | Formenti, Beatrice | Gaviraghi, Alberto | Giacomet, Vania | Goletti, Delia | Gualano, Gina | Matteelli, Alberto | Migliori, Giovanni Battista | Motta, Ilaria | Palmieri, Fabrizio | Pontali, Emanuele | Prestileo, Tullio | Riccardi, Niccolò | Saderi, Laura | Saporiti, Matteo | Sotgiu, Giovanni | Spanevello, Antonio | Stochino, Claudia | Tadolini, Marina | Torre, Alessandro | Villa, Simone | Visca, Dina | Kurhasani, Xhevat | Furjani, Mohammed | Rasheed, Najia | Danila, Edvardas | Diktanas, Saulius | Ridaura, Ruy López | Luna López, Fátima Leticia | Torrico, Marcela Muñoz | Rendon, Adrian | Akkerman, Onno | Chizaram, Onyeaghala | Al-Abri, Seif | Alyaquobi, Fatma | Althohli, Khalsa | Aguirre, Sarita | Teixeira, Rosarito Coronel | de Egea, Viviana | Irala, Sandra | Medina, Angélica | Sequera, Guillermo | Sosa, Natalia | Vázquez, Fátima | Llanos-Tejada, Félix | Manga, Selene | Villanueva-Villegas, Renzo | Araujo, David | Sales Marques, Raquel Duartetânia | Socaci, Adriana | Barkanova, Olga | Bogorodskaya, Maria | Borisov, Sergey | Mariandyshev, Andrei | Kaluzhenina, Anna | Vukicevic, Tatjana Adzic | Stosic, Maja | Beh, Darius | Ng, Deborah | Ong, Catherine W.M. | Solovic, Ivan | Dheda, Keertan | Gina, Phindile | Caminero, José | de Souza Galvão, Maria Luiza | Dominguez-Castellano, Angel | García-García, José-María | Pinargote, Israel Molina | Fernandez, Sarai Quirós | Sánchez-Montalvá, Adrián | Huguet, Eva Tabernero | Murguiondo, Miguel Zabaleta | Bart, Pierre-Alexandre | Mazza-Stalder, Jesica | d'Ambrosio, Lia | Kamolwat, Phalin | Bakko, Freya | Barnacle, James | Bird, Sophie | Brown, Annabel | Chandran, Shruthi | Killington, Kieran | Man, Kathy | Papineni, Padmasayee | Ritchie, Flora | Tiberi, Simon | Utjesanovic, Natasa | Zenner, Dominik | Hearn, Jasie | Heysell, Scott | Young, Laura
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CCSD ; European Respiratory Society -
International audience.
Background Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end of cohort time. All patients had TB and COVID-19; for analysis purposes, deaths were attributed to TB, COVID-19 or both. Survival analysis was performed using Cox proportional risk-regression models, and the log-rank test was used to compare survival and mortality attributed to TB, COVID-19 or both. Results Overall, 788 patients with COVID-19 and TB (active or sequelae) were recruited from 31 countries, and 10.8% (n=85) died during the observation period. Survival was significantly lower among patients whose death was attributed to TB and COVID-19 versus those dying because of either TB or COVID-19 alone (p<0.001). Significant adjusted risk factors for TB mortality were higher age (hazard ratio (HR) 1.05, 95% CI 1.03–1.07), HIV infection (HR 2.29, 95% CI 1.02–5.16) and invasive ventilation (HR 4.28, 95% CI 2.34–7.83). For COVID-19 mortality, the adjusted risks were higher age (HR 1.03, 95% CI 1.02–1.04), male sex (HR 2.21, 95% CI 1.24–3.91), oxygen requirement (HR 7.93, 95% CI 3.44–18.26) and invasive ventilation (HR 2.19, 95% CI 1.36–3.53). Conclusions In our global cohort, death was the outcome in >10% of patients with TB and COVID-19. A range of demographic and clinical predictors are associated with adverse outcomes.
