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TopBP1 biomolecular condensates: a new therapeutic target in advanced-stage colorectal cancer

Archive ouverte | Morano, Laura | CCSD

Abstract In cancer cells, ATR signaling is crucial to tolerate the intrinsically high damage levels that normally block replication fork progression. Assembly of TopBP1, a multifunctional scaffolding protein, into condensates is r...

KIF2C-induced nuclear condensation concentrates PLK1 and phosphorylated BRCA2 at the kinetochore microtubules in mitosis

Archive ouverte | Skobelkina, Anastasiia | CCSD

SUMMARY During mitosis, the human microtubule depolymerase KIF2C increases the turnover of kinetochore-microtubule attachments. This facilitates the correction of attachment errors. Moreover, BRCA2 phosphorylated at Thr207 by PLK1...

TopBP1 assembles nuclear condensates to switch on ATR signalling

Archive ouverte | Frattini, Camilla | CCSD

International audience. ATR checkpoint signalling is crucial for cellular responses to DNA replication impediments. Using an optogenetic platform, we show that TopBP1, the main activator of ATR, selfassembles extens...

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